31 lines
1.8 KiB
Plaintext
31 lines
1.8 KiB
Plaintext
This model package provides NEURON codes for a multi-compartment model described
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in Zhou Y, Carney LH, Colburn HS (2005). The model simulates recent physiological
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results from the gerbil medial superior olive (MSO) that reveal that blocking
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glycinergic inhibition can shift the tuning for the interaural time difference (ITD)
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of the cell (Brand et al., 2002).
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The model has a bipolar structure and incorporates two anatomic observations
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in the MSO: (1) the axon arises from the dendrite that receives ipsilateral
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inputs (Smith, 1995); and (2) inhibitory synapses are located primarily
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on the soma in adult animals. Specific Hodgkin-Huxley type of ionic channels
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are inserted into the axon to generate action potentials: fast sodium (Ina),
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low threshold potassium (ILTK), high threshold potassium (IHTK),
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hyperpolarization-active inward current (Ih), and the leakage channel (Il).
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The kinetics of all channels are based on the model of Type II cells in the
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anteroventral cochlear nuclei (Rothman and Manis, 2003c). The soma has only
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fast sodium channels. Ionic channels and the driving function for synaptic
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inputs are described in .mod files. The hoc files describe simulation procedures
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for modeling neural responses to ITDs (MSO_Zhouetal_2005.hoc) and a test kit
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for exploring input characteristics (test_inputs.hoc). Use NEURON command nrnivmodl
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to compile *.mod files, and then execute a *.hoc file. Please refer to NEURON
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documentations for further instructions on compiling mod files and
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launching hoc files on different operation systems.
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The file MSO_Zhouetal_2005.hoc produces the rate-ITD responses
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in Figures. 5, 6, 8, 11 in Zhou Y, Carney LH, Colburn HS (2005).
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Go to http://www.bu.edu/dbin/binaural/MSOdemo for more instructions on using the model.
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Any questions for implementing the model should be directed to Yi Zhou (yizhou@bu.edu).
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